A Prospective Hospital-Based Study of the Clinical Impact of Non–Severe Acute Respiratory Syndrome (Non-SARS)–Related Human Coronavirus Infection
Identifieur interne : 004103 ( Main/Exploration ); précédent : 004102; suivant : 004104A Prospective Hospital-Based Study of the Clinical Impact of Non–Severe Acute Respiratory Syndrome (Non-SARS)–Related Human Coronavirus Infection
Auteurs : Jorge Garbino ; Sophie Crespo ; J.-D. Aubert [Suisse] ; Thierry Rochat ; Beatrice Ninet ; Christelle Deffernez ; Werner Wunderli ; Jean-Claude Pache ; Paola M. Soccal ; Laurent Kaiser [Suisse]Source :
- Clinical Infectious Diseases [ 1058-4838 ] ; 2006.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Coronavirus (), Coronavirus (isolement et purification), Coronavirus humain 229E (isolement et purification), Coronavirus humain OC43 (isolement et purification), Femelle, Humains, Infections à coronavirus (virologie), Liquide de lavage bronchoalvéolaire (virologie), Maladies pulmonaires (virologie), Mâle, Suisse, Sujet âgé, Transplantation pulmonaire (effets indésirables), Études prospectives.
- MESH :
- effets indésirables : Transplantation pulmonaire.
- isolement et purification : Coronavirus, Coronavirus humain 229E, Coronavirus humain OC43.
- virologie : Infections à coronavirus, Liquide de lavage bronchoalvéolaire, Maladies pulmonaires.
- Adolescent, Adulte, Adulte d'âge moyen, Coronavirus, Femelle, Humains, Mâle, Suisse, Sujet âgé, Études prospectives.
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Bronchoalveolar Lavage Fluid (virology), Coronavirus, Coronavirus (classification), Coronavirus (isolation & purification), Coronavirus 229E, Human (isolation & purification), Coronavirus Infections (virology), Coronavirus OC43, Human (isolation & purification), Female, Hospital, Human, Humans, Lung Diseases (virology), Lung Transplantation (adverse effects), Male, Middle Aged, Prospective Studies, Severe acute respiratory syndrome, Switzerland, Symptomatology.
- MESH :
- geographic : Switzerland.
- adverse effects : Lung Transplantation.
- classification : Coronavirus.
- isolation & purification : Coronavirus, Coronavirus 229E, Human, Coronavirus OC43, Human.
- virology : Bronchoalveolar Lavage Fluid, Coronavirus Infections, Lung Diseases.
- Adolescent, Adult, Aged, Female, Humans, Male, Middle Aged, Prospective Studies.
Abstract
Background. In addition to the human coronaviruses (HCoVs) OC43 and 229E, which have been known for decades to cause infection in humans, 2 new members of this genus have recently been identified: HCoVs NL63 and HKU1. Their impact as a cause of respiratory tract disease in adults at risk for complications needs to be established. Methods. We prospectively assessed the clinical impact of coronavirus infection (excluding cases of severe acute respiratory syndrome) among hospitalized adults. All patients with respiratory disease for whom bronchoalveolar lavage was performed were screened by reverse-transcriptase polymerase chain reaction for the presence of all 4 HCoVs. Results. HCoV was identified in 29 (5.4%) of 540 bronchoalveolar lavage fluid specimens from 279 subjects (mean age, 51 years; 63% male). HCoV OC43 was identified most frequently (12 isolates), followed by 229E (7 isolates), NL63 (6 isolates), and HKU1 (4 isolates). In all, 372 (69%) of 540 bronchoalveolar lavage fluid specimens were negative for bacteria, and 2 persons were coinfected with other respiratory viruses. Transplantation was the most common underlying condition. Of the 29 patients who had HCoV identified in their bronchoalveolar lavage fluid specimens, 9 (31%) were hospitalized in the intensive care unit, 22 (76%) presented to the hospital with acute respiratory symptoms, 16 (55%) presented with cough and/or sputum, 13 (45%) presented with dyspnea, 16 (55%) had experienced prior respiratory infection, and 18 (62%) had a new infiltrate that was visible on chest radiograph. The most frequent final diagnosis was a lower respiratory tract infection. Conclusions. The recently discovered HCoVs NL63 and HKU1 contribute significantly to the overall spectrum of coronavirus infection. Our study also suggests that coronaviruses contribute to respiratory symptoms in most cases.
Url:
DOI: 10.1086/507898
Affiliations:
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Aubert</name><affiliation wicri:level="3"><country xml:lang="fr">Suisse</country><wicri:regionArea>Division of Pulmonary Medicine, Department of Medicine, University Hospital of Lausanne, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Rochat, Thierry" sort="Rochat, Thierry" uniqKey="Rochat T" first="Thierry" last="Rochat">Thierry Rochat</name><affiliation><wicri:noCountry code="subField">Geneva</wicri:noCountry></affiliation></author><author><name sortKey="Ninet, Beatrice" sort="Ninet, Beatrice" uniqKey="Ninet B" first="Beatrice" last="Ninet">Beatrice Ninet</name><affiliation><wicri:noCountry code="subField">Geneva</wicri:noCountry></affiliation></author><author><name sortKey="Deffernez, Christelle" sort="Deffernez, Christelle" uniqKey="Deffernez C" first="Christelle" last="Deffernez">Christelle Deffernez</name><affiliation><wicri:noCountry code="subField">Geneva</wicri:noCountry></affiliation></author><author><name sortKey="Wunderli, Werner" sort="Wunderli, Werner" uniqKey="Wunderli W" first="Werner" last="Wunderli">Werner Wunderli</name><affiliation><wicri:noCountry code="subField">Geneva</wicri:noCountry></affiliation></author><author><name sortKey="Pache, Jean Claude" sort="Pache, Jean Claude" uniqKey="Pache J" first="Jean-Claude" last="Pache">Jean-Claude Pache</name><affiliation><wicri:noCountry code="subField">Geneva</wicri:noCountry></affiliation></author><author><name sortKey="Soccal, Paola M" sort="Soccal, Paola M" uniqKey="Soccal P" first="Paola M." last="Soccal">Paola M. Soccal</name><affiliation></affiliation><affiliation><wicri:noCountry code="subField">Geneva</wicri:noCountry></affiliation></author><author><name sortKey="Kaiser, Laurent" sort="Kaiser, Laurent" uniqKey="Kaiser L" first="Laurent" last="Kaiser">Laurent Kaiser</name><affiliation></affiliation><affiliation></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Suisse</country></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Suisse</country><wicri:regionArea>Reprints or correspondence: Dr. Laurent Kaiser, Div. of Infectious Diseases, Central Laboratory of Virology, University Hospitals of Geneva, 24 Rue Micheli-du-Crest, 1211 Geneva 14</wicri:regionArea><wicri:noRegion>1211 Geneva 14</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Clinical Infectious Diseases</title><title level="j" type="abbrev">Clinical Infectious Diseases</title><idno type="ISSN">1058-4838</idno><idno type="eISSN">1537-6591</idno><imprint><publisher>The University of Chicago Press</publisher><date type="published">2006</date><biblScope unit="vol">43</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1009">1009</biblScope><biblScope unit="page" to="1015">1015</biblScope></imprint><idno type="ISSN">1058-4838</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1058-4838</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Bronchoalveolar Lavage Fluid (virology)</term><term>Coronavirus</term><term>Coronavirus (classification)</term><term>Coronavirus (isolation & purification)</term><term>Coronavirus 229E, Human (isolation & purification)</term><term>Coronavirus Infections (virology)</term><term>Coronavirus OC43, Human (isolation & purification)</term><term>Female</term><term>Hospital</term><term>Human</term><term>Humans</term><term>Lung Diseases (virology)</term><term>Lung Transplantation (adverse effects)</term><term>Male</term><term>Middle Aged</term><term>Prospective Studies</term><term>Severe acute respiratory syndrome</term><term>Switzerland</term><term>Symptomatology</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Coronavirus ()</term><term>Coronavirus (isolement et purification)</term><term>Coronavirus humain 229E (isolement et purification)</term><term>Coronavirus humain OC43 (isolement et purification)</term><term>Femelle</term><term>Humains</term><term>Infections à coronavirus (virologie)</term><term>Liquide de lavage bronchoalvéolaire (virologie)</term><term>Maladies pulmonaires (virologie)</term><term>Mâle</term><term>Suisse</term><term>Sujet âgé</term><term>Transplantation pulmonaire (effets indésirables)</term><term>Études prospectives</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Switzerland</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Lung Transplantation</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Transplantation pulmonaire</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Coronavirus</term><term>Coronavirus 229E, Human</term><term>Coronavirus OC43, Human</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus</term><term>Coronavirus humain 229E</term><term>Coronavirus humain OC43</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Liquide de lavage bronchoalvéolaire</term><term>Maladies pulmonaires</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Bronchoalveolar Lavage Fluid</term><term>Coronavirus Infections</term><term>Lung Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prospective Studies</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Coronavirus</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Suisse</term><term>Sujet âgé</term><term>Études prospectives</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Coronavirus</term><term>Homme</term><term>Hôpital</term><term>Symptomatologie</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Suisse</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Background. In addition to the human coronaviruses (HCoVs) OC43 and 229E, which have been known for decades to cause infection in humans, 2 new members of this genus have recently been identified: HCoVs NL63 and HKU1. Their impact as a cause of respiratory tract disease in adults at risk for complications needs to be established. Methods. We prospectively assessed the clinical impact of coronavirus infection (excluding cases of severe acute respiratory syndrome) among hospitalized adults. All patients with respiratory disease for whom bronchoalveolar lavage was performed were screened by reverse-transcriptase polymerase chain reaction for the presence of all 4 HCoVs. Results. HCoV was identified in 29 (5.4%) of 540 bronchoalveolar lavage fluid specimens from 279 subjects (mean age, 51 years; 63% male). HCoV OC43 was identified most frequently (12 isolates), followed by 229E (7 isolates), NL63 (6 isolates), and HKU1 (4 isolates). In all, 372 (69%) of 540 bronchoalveolar lavage fluid specimens were negative for bacteria, and 2 persons were coinfected with other respiratory viruses. Transplantation was the most common underlying condition. Of the 29 patients who had HCoV identified in their bronchoalveolar lavage fluid specimens, 9 (31%) were hospitalized in the intensive care unit, 22 (76%) presented to the hospital with acute respiratory symptoms, 16 (55%) presented with cough and/or sputum, 13 (45%) presented with dyspnea, 16 (55%) had experienced prior respiratory infection, and 18 (62%) had a new infiltrate that was visible on chest radiograph. The most frequent final diagnosis was a lower respiratory tract infection. Conclusions. The recently discovered HCoVs NL63 and HKU1 contribute significantly to the overall spectrum of coronavirus infection. Our study also suggests that coronaviruses contribute to respiratory symptoms in most cases.</div></front></TEI><affiliations><list><country><li>Suisse</li></country><region><li>Canton de Vaud</li></region><settlement><li>Lausanne</li></settlement></list><tree><noCountry><name sortKey="Crespo, Sophie" sort="Crespo, Sophie" uniqKey="Crespo S" first="Sophie" last="Crespo">Sophie Crespo</name><name sortKey="Deffernez, Christelle" sort="Deffernez, Christelle" uniqKey="Deffernez C" first="Christelle" last="Deffernez">Christelle Deffernez</name><name sortKey="Garbino, Jorge" sort="Garbino, Jorge" uniqKey="Garbino J" first="Jorge" last="Garbino">Jorge Garbino</name><name sortKey="Ninet, Beatrice" sort="Ninet, Beatrice" uniqKey="Ninet B" first="Beatrice" last="Ninet">Beatrice Ninet</name><name sortKey="Pache, Jean Claude" sort="Pache, Jean Claude" uniqKey="Pache J" first="Jean-Claude" last="Pache">Jean-Claude Pache</name><name sortKey="Rochat, Thierry" sort="Rochat, Thierry" uniqKey="Rochat T" first="Thierry" last="Rochat">Thierry Rochat</name><name sortKey="Soccal, Paola M" sort="Soccal, Paola M" uniqKey="Soccal P" first="Paola M." last="Soccal">Paola M. Soccal</name><name sortKey="Wunderli, Werner" sort="Wunderli, Werner" uniqKey="Wunderli W" first="Werner" last="Wunderli">Werner Wunderli</name></noCountry><country name="Suisse"><region name="Canton de Vaud"><name sortKey="Aubert, J D" sort="Aubert, J D" uniqKey="Aubert J" first="J.-D." last="Aubert">J.-D. Aubert</name></region><name sortKey="Kaiser, Laurent" sort="Kaiser, Laurent" uniqKey="Kaiser L" first="Laurent" last="Kaiser">Laurent Kaiser</name><name sortKey="Kaiser, Laurent" sort="Kaiser, Laurent" uniqKey="Kaiser L" first="Laurent" last="Kaiser">Laurent Kaiser</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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